Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Acetyl-cholinesterase enzyme inhibitory effect of Calophyllum species

Gwendoline Cheng Lian Ee¹ , Soek Sin Teh¹, Siau Hui Mah², Nur Ain Jamaluddin¹, Muhamad Syarik bin Muhamad Sahimi¹, Zuraini Ahmad³

¹Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang; ²School of Biosciences, Taylors University, Lakeside Campus, 47500 Subang Jaya; ³Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

For correspondence:- Gwendoline Ee Email: gwen@upm.edu.my Tel:+60389466785

Received: 13 October 2014 Accepted: 29 August 2015 Published: 29 November 2015

Citation: Ee GC, Teh SS, Mah SH, Jamaluddin NA, Sahimi MS, Ahmad Z. Acetyl-cholinesterase enzyme inhibitory effect of Calophyllum species. Trop J Pharm Res 2015; 14(11):2005-2008 doi: 10.4314/tjpr.v14i10.8

© 2015 The authors.
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Abstract

Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species.

Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method.

Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 µg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.

Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.